2-Chloro-4-difluoromethoxy-pyridine

CAS No. 1206978-15-5
Cat. No. CS-D0411
Purity≥98%
MDL No.MFCD13185848

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FedEx Limited Quantities Ground	$0.00
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2-Chloro-4-difluoromethoxy-pyridine|CS-D0411

Structure of 1206978-15-5

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Description

2-Chloro-4-difluoromethoxy-pyridine features a difluoromethoxy group at the pyridine 4-position, enhancing electron-withdrawing character and metabolic stability. This bench-stable heterocycle integrates readily into pharmaceutical intermediates, offering improved solubility and compatibility in cross-coupling reactions under standard conditions.

Application

2-Chloro-4-difluoromethoxy-pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The difluoromethoxy group enhances metabolic stability and modulates electronic properties, while the compound exhibits good bench stability and compatibility with standard synthetic workflows.

General Information

CAS No. 1206978-15-5
Cat. No. CS-D0411
Purity ≥98%
MDL No. MFCD13185848
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₂NO
Molecular Weight 179.55
Synonym(s) 2-Chloro-4-(difluoromethoxy)pyridine
SMILES FC(F)OC1=CC(Cl)=NC=C1

Computational Chemistry Data

TPSA 22.12
LogP 2.3364
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-difluoromethoxy-pyridine

CAS No. 1206978-15-5

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