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Structure of 1214323-40-6
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5-Chloro-2-(difluoromethoxy)pyridine features a difluoromethoxy group at the 2-position, enhancing electron-withdrawal and metabolic stability. The chloro substituent at the 5-position enables selective functionalization in late-stage derivatization. This pyridine scaffold integrates readily into bioactive molecules, offering favorable solubility and compatibility with common coupling reactions under standard conditions.
5-Chloro-2-(difluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C5 position via palladium-catalyzed cross-coupling reactions. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the chloropyridine moiety supports orthogonal reactivity in heterocyclic synthesis. This compound exhibits excellent bench stability and facilitates efficient incorporation into API scaffolds through standard coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: