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Structure of 61272-76-2
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4-Fluoro-2-iodoaniline features a strategically positioned fluorine atom and iodine substituent on the aniline scaffold, enabling selective cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity in palladium-catalyzed transformations, while the iodide serves as a high-efficiency coupling handle. This combination delivers precise functionalization in complex molecule synthesis under standard conditions.
4-Fluoro-2-iodoaniline serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl scaffolds under standard Suzuki-Miyaura and Stille conditions. The ortho-iodo group exhibits high reactivity, while the para-fluoro substituent provides enhanced metabolic stability and favorable electronic modulation in target molecule design. Bench-stable and readily purified by column chromatography, it facilitates streamlined synthesis of complex heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅱ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P302+P352-P304+P340
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Lot numbers can be found on the outside label of a product: