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CS-W001157 4
Total: USD 88.00

4-Fluoro-2-iodoaniline

  • CAS No. 61272-76-2

  • Cat. No. CS-W004776
  • Purity≥98%
  • MDL No.MFCD00042584
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-iodoaniline|CS-W004776

Structure of 61272-76-2

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Description

4-Fluoro-2-iodoaniline features a strategically positioned fluorine atom and iodine substituent on the aniline scaffold, enabling selective cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity in palladium-catalyzed transformations, while the iodide serves as a high-efficiency coupling handle. This combination delivers precise functionalization in complex molecule synthesis under standard conditions.

Application

4-Fluoro-2-iodoaniline serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl scaffolds under standard Suzuki-Miyaura and Stille conditions. The ortho-iodo group exhibits high reactivity, while the para-fluoro substituent provides enhanced metabolic stability and favorable electronic modulation in target molecule design. Bench-stable and readily purified by column chromatography, it facilitates streamlined synthesis of complex heterocycles and pharmaceutical intermediates.

General Information

  • CAS No. 61272-76-2
  • Cat. No. CS-W004776
  • Purity ≥98%
  • MDL No. MFCD00042584
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FIN
  • Molecular Weight 237.01
  • Synonym(s) Benzenamine, 4-fluoro-2-iodo-
  • SMILES FC1=CC(=C(N)C=C1)I

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0125
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

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