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CS-W001157 4
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3-Fluoro-4-iodo-2-methoxypyridine

  • CAS No. 1227595-09-6

  • Cat. No. CS-0636381
  • Molecule weight253.01
  • Purity≥95%
  • MDL No.MFCD16611140

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-iodo-2-methoxypyridine|CS-0636381

Structure of 1227595-09-6

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General Information

  • CAS No. 1227595-09-6
  • Cat. No. CS-0636381
  • Purity ≥95%
  • MDL No. MFCD16611140
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FINO
  • Molecular Weight 253.01
  • Synonym(s) None
  • SMILES COC1=NC=CC(I)=C1F

Description

3-Fluoro-4-iodo-2-methoxypyridine features a strategically positioned fluorine and iodine substituent on a pyridine core, enabling efficient cross-coupling transformations. The methoxy group enhances solubility and modulates electronic properties, while the electron-deficient ring facilitates palladium-catalyzed reactions. This compound serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

3-Fluoro-4-iodo-2-methoxypyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of substituted pyridine scaffolds. The iodide group facilitates palladium-catalyzed coupling reactions with broad functional group tolerance, while the fluorine and methoxy substituents provide electronic modulation and steric control. This compound exhibits excellent bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.8339
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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