4-Bromo-2,3-difluoropyridine

CAS No. 1227597-53-6
Cat. No. CS-0443061
Purity≥98%
MDL No.MFCD16609910

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

4-Bromo-2,3-difluoropyridine is a fluorinated heterocyclic building block featuring complementary halogen handles for cross-coupling reactions. The electron-deficient pyridine core enables efficient palladium-catalyzed transformations, while the difluoro substitution enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates.

Application

4-Bromo-2,3-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine and electron-deficient pyridine core. The ortho-fluorine substituents enhance metabolic stability and facilitate directed metalation. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

CAS No. 1227597-53-6
Cat. No. CS-0443061
Purity ≥98%
MDL No. MFCD16609910
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂BrF₂N
Molecular Weight 193.98
Synonym(s) None
SMILES C1=CN=C(C(=C1Br)F)F

Computational Chemistry Data

TPSA 12.89
LogP 2.1223
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Bromo-2,3-difluoropyridine

CAS No. 1227597-53-6

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