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CS-W001157 4
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Methyl 5-bromo-3-hydroxypicolinate

  • CAS No. 1242320-57-5

  • Cat. No. CS-W022863
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Methyl 5-bromo-3-hydroxypicolinate|CS-W022863

Structure of 1242320-57-5

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Description

Methyl 5-bromo-3-hydroxypicolinate features a brominated pyridine core with strategically positioned hydroxyl and ester functionalities. This combination enables direct incorporation into diverse synthetic scaffolds, particularly in medicinal chemistry and agrochemical development. The molecule exhibits enhanced reactivity at the C5 position due to the electron-withdrawing bromo group, while the adjacent hydroxyl supports hydrogen bonding and modulates solubility. Bench-stable under standard conditions, it serves as a key intermediate for further derivatization via cross-coupling or nucleophilic substitution reactions.

Application

Methyl 5-bromo-3-hydroxypicolinate serves as a versatile building block in synthetic medicinal chemistry, enabling direct functionalization at the 3-position via nucleophilic substitution or oxidation. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the hydroxyl moiety offers controlled derivatization potential. Bench-stable and compatible with standard purification methods, it functions effectively in the construction of bioactive heterocycles and API intermediates requiring regioselective substitution.

General Information

  • CAS No. 1242320-57-5
  • Cat. No. CS-W022863
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₃
  • Molecular Weight 232.03
  • Synonym(s) 2-Pyridinecarboxylic acid, 5-bromo-3-hydroxy-, methyl ester
  • SMILES O=C(OC)C1=NC=C(Br)C=C1O

Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.3363
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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