(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid

Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid
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CAS No. 178432-48-9
Cat. No. CS-0100207
Purity≥95%
MDL No.MFCD07371961

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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid|CS-0100207

Structure of 178432-48-9

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Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid features a chiral center at the C2 position and incorporates a fluorenylmethyl carbamate (Fmoc) protecting group for peptide synthesis. The pendant 3-hydroxyphenyl moiety provides a polar, aromatic handle for conjugation or derivatization. This compound serves as a key building block in the synthesis of bioactive peptides and peptidomimetics.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid serves as a chiral building block for peptide synthesis and bioactive molecule construction. The Fmoc group enables orthogonal protection, while the pendant phenolic hydroxyl supports further derivatization. This stable, bench-friendly amino acid derivative facilitates efficient coupling reactions and simplifies purification in solid-phase and solution-phase workflows.

General Information

CAS No. 178432-48-9
Cat. No. CS-0100207
Purity ≥95%
MDL No. MFCD07371961
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₁NO₅
Molecular Weight 403.43
Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-3-hydroxy-L-phenylalanine
SMILES O=C([C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CC4=CC=CC(O)=C4)O

Computational Chemistry Data

TPSA 95.86
LogP 3.9266
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Tyrosine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid

CAS No. 178432-48-9

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