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CS-W001157 4
Total: USD 88.00

(3-Hydroxy-5-methylphenyl)boronic acid

  • CAS No. 1256345-79-5

  • Cat. No. CS-0174506
  • Molecule weight151.96
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Hydroxy-5-methylphenyl)boronic acid|CS-0174506

Structure of 1256345-79-5

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General Information

  • CAS No. 1256345-79-5
  • Cat. No. CS-0174506
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BO₃
  • Molecular Weight 151.96
  • Synonym(s) 3-Hydroxy-5-methylphenylboronic acid
  • SMILES CC1=CC(B(O)O)=CC(O)=C1

Description

This boronate moiety features a hydroxyl group ortho to the boronic acid, enhancing solubility and stability under standard conditions. The methyl substituent at the para position imparts electron-donating character, promoting efficient coupling in Suzuki-Miyaura reactions. Ideal for constructing complex phenolic architectures with high functional group tolerance.

Application

(3-Hydroxy-5-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of biaryl scaffolds under mild conditions. The ortho-hydroxyl group enhances regioselectivity and provides a handle for downstream derivatization or metal chelation. Bench-stable and readily purified by recrystallization, it exhibits good functional group tolerance, facilitating integration into complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.61958
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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