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Structure of 1260663-68-0
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3-Amino-5-chloropyrazine-2-carboxylic acid features a pyrazine core functionalized with amino, chloro, and carboxylic acid groups at strategic positions. This trifunctional scaffold enables direct integration into bioactive molecule design, particularly in kinase inhibitors and pharmaceutical intermediates. The electron-deficient pyrazine ring enhances reactivity in coupling reactions, while the carboxylic acid facilitates salt formation and solubility optimization under standard conditions.
3-Amino-5-chloropyrazine-2-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct incorporation into pyrazine-based scaffolds via amide coupling or nucleophilic substitution. The amino and carboxylic acid groups provide orthogonal functionality for conjugation, while the chloro substituent facilitates palladium-catalyzed cross-coupling reactions. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of pharmaceutical intermediates and functionalized ligands in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: