6-Chloro-2,7-naphthyridin-1(2H)-one

CAS No. 1260663-93-1
Cat. No. CS-0100040
Molecule weight180.59
Purity≥97%
MDL No.MFCD18250873

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-2,7-naphthyridin-1(2H)-one|CS-0100040

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General Information

CAS No. 1260663-93-1
Cat. No. CS-0100040
Purity ≥97%
MDL No. MFCD18250873
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClN₂O
Molecular Weight 180.59
Synonym(s) 6-Chloro-2H-2,7phthyridin-1-one
SMILES O=C1NC=CC2=CC(Cl)=NC=C12

Description

6-Chloro-2,7-naphthyridin-1(2H)-one features a rigid, electron-deficient naphthyridine core paired with a chlorine substituent at the 6-position, enhancing its utility in medicinal chemistry. This bench-stable heterocycle serves as a key scaffold for kinase inhibitors and DNA-targeting agents, offering improved metabolic stability and targeted binding affinity in drug discovery campaigns.

Application

6-Chloro-2,7-naphthyridin-1(2H)-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its chloro group facilitates palladium-catalyzed cross-coupling reactions, while the naphthyridinone core provides a rigid, planar scaffold with favorable pharmacophoric properties. The compound exhibits excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 45.75
LogP 1.5765
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-2,7-naphthyridin-1(2H)-one

CAS No. 1260663-93-1

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