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Tert-butyl 3-(chlorosulfonyl)piperidine-1-carboxylate

  • CAS No. 1260664-44-5

  • Cat. No. CS-0309017
  • Molecule weight283.77
  • Purity≥97%
  • MDL No.MFCD18249904

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 3-(chlorosulfonyl)piperidine-1-carboxylate|CS-0309017

Structure of 1260664-44-5

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General Information

  • CAS No. 1260664-44-5
  • Cat. No. CS-0309017
  • Purity ≥97%
  • MDL No. MFCD18249904
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈ClNO₄S
  • Molecular Weight 283.77
  • Synonym(s) 1-Piperidinecarboxylic acid, 3-(chlorosulfonyl)-, 1,1-dimethylethyl ester
  • SMILES O=C(N1CC(S(=O)(Cl)=O)CCC1)OC(C)(C)C

Description

Tert-butyl 3-(chlorosulfonyl)piperidine-1-carboxylate is a bench-stable, moisture-tolerant reagent featuring a chlorosulfonyl group at the piperidine 3-position. This electrophilic handle enables selective sulfonation of nucleophiles, streamlining access to functionalized piperidine scaffolds in medicinal chemistry and peptide modification workflows.

Application

Tert-butyl 3-(chlorosulfonyl)piperidine-1-carboxylate serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles and piperidine-based scaffolds. The chlorosulfonyl group enables efficient derivatization via nucleophilic substitution, facilitating the introduction of diverse amine functionalities. Its tert-butyl carbamate protection offers stability under basic conditions and allows for straightforward deprotection during late-stage functionalization. This reagent is particularly valuable in medicinal chemistry workflows requiring orthogonally protected piperidines with high synthetic flexibility.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P280-P301+P330+P331-P304+P340

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Computational Chemistry Data

  • TPSA   63.68
  • LogP   1.9545
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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