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CS-W001157 4
Total: USD 88.00

4-Hydroxybenzyl alcohol

  • CAS No. 623-05-2

  • Cat. No. CS-W019891
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD00004658

*For research and further manufacturing use only, not for direct human use.

4-Hydroxybenzyl alcohol|CS-W019891

Structure of 623-05-2

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General Information

  • CAS No. 623-05-2
  • Cat. No. CS-W019891
  • Purity ≥97%
  • MDL No. MFCD00004658
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₂
  • Molecular Weight None
  • Synonym(s) 4-Methylolphenol
  • SMILES OCC1=CC=C(O)C=C1

Description

5'-O-DMT-2'-OMe-Benzoyl-Adenosine-CE Phosphoramidite is a phosphoramdite monomer used in the synthesis of native-like crosslinked duplex RNA.

Application

4-Hydroxybenzyl alcohol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to bioactive heterocycles and pharmaceutical intermediates. Its dual functionality—phenolic hydroxyl and primary alcohol—supports orthogonal transformations, including etherification, esterification, and oxidation to the aldehyde. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      1338215-45-4
    • ~89%
    • In-stock
      4-Hydroxybenzyl alcohol|CS-W019891
      623-05-2

    References

    • Dibakar, Mullick; Prakash, Anjanappa; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5338 - 5341
  • Route2
    • p-Hydroxybenzaldehyde Bisoprolol Impurity|CS-0229513
      123-08-0
    • ~99%
    • In-stock
      4-Hydroxybenzyl alcohol|CS-W019891
      623-05-2

    References

    • Zhang, Miao; Rouch, William D.; McCulla, Ryan D. European Journal of Organic Chemistry, 2012 , # 31 p. 6187 - 6196
  • Route3

    References

    • Kurane, Rajanikant; Gaikwad, Vipul; Jadhav, Jagannath; Salunkhe, Rajashri; Rashinkar, Gajanan Tetrahedron Letters, 2012 , vol. 53, # 47 p. 6361 - 6366,6

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319-H412
Precautionary Statements : P264-P273-P280-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.8845
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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