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CS-W001157 4
Total: USD 88.00

Lamivudine

  • CAS No. 134678-17-4

  • Cat. No. CS-2230
  • Molecule weight229.26
  • Purity≥98%
  • MDL No.MFCD00869739

*For research and further manufacturing use only, not for direct human use.

Lamivudine|CS-2230

Structure of 134678-17-4

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General Information

  • CAS No. 134678-17-4
  • Cat. No. CS-2230
  • Purity ≥98%
  • MDL No. MFCD00869739
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁N₃O₃S
  • Molecular Weight 229.26
  • Synonym(s) BCH-189
  • SMILES OC[C@H]1SC[C@@H](N2C(N=C(N)C=C2)=O)O1

Description

.

Application

Lamivudine serves as a well-established nucleoside reverse transcriptase inhibitor, featuring a cytosine analog with a stable 3'-thia modification that enhances metabolic resistance. It functions as a critical building block in antiretroviral synthesis, enabling efficient incorporation into oligonucleotide chains via standard phosphoramidite coupling protocols. The compound exhibits excellent bench stability, predictable reactivity, and high compatibility with diverse protecting group strategies, making it a reliable scaffold for the synthesis of HIV and hepatitis B therapeutics.

Synthesis

  • Route1
    • null|null
      131086-21-0
    • ~32%
    • In-stock
      Lamivudine|CS-2230
      134678-17-4

    References

    • CHONG KUN DANG PHARMACEUTICAL CORP. Patent: WO2007/91753 A1, 2007 ; Location in patent: Page/Page column 14-15 ;
  • Route2
    • (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate|CS-0698801
      147027-10-9
    • Salicylic acid, ≥99%|CS-1268363
      69-72-7
    • ~%
    • In-stock
      Lamivudine|CS-2230
      134678-17-4

    References

    • WO2009/69014 A1, ; Page/Page column 6 ;
  • Route3
    • (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate|CS-0698801
      147027-10-9
    • ~%
    • (-)-Menthol, ≥99%|CS-1268949
      2216-51-5
    • In-stock
      Lamivudine|CS-2230
      134678-17-4

    References

    • US2011/282046 A1, ; Page/Page column 11-12 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H361
Precautionary Statements : P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   90.37
  • LogP   -0.5941
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   2

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