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CS-W001157 4
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Ethyl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate

  • CAS No. 143615-00-3

  • Cat. No. CS-0504135
  • Molecule weight209.24
  • Purity≥98%
  • MDL No.MFCD11111470

*For research and further manufacturing use only, not for direct human use.

Ethyl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate|CS-0504135

Structure of 143615-00-3

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General Information

  • CAS No. 143615-00-3
  • Cat. No. CS-0504135
  • Purity ≥98%
  • MDL No. MFCD11111470
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO₃
  • Molecular Weight 209.24
  • Synonym(s) Cabazitaxel Impurity 24 ( (2R,3S)-3-Amino-2-hydroxy-3-phenylpropionic Acid Ethyl Ester)
  • SMILES N[C@@H](C1=CC=CC=C1)[C@@H](O)C(OCC)=O

Synthesis

  • Route1
    • null|null
      144787-20-2
    • ~87%
    • Ethyl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate|CS-0504135
      143615-00-3

    References

    • Commercon; Bezard; Bernard; Bourzat Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
  • Route2
    • null|null
      860646-95-3
    • ~%
    • Ethyl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate|CS-0504135
      143615-00-3

    References

    • Torssell, Staffan; Kienle, Marcel; Somfai, Peter Angewandte Chemie - International Edition, 2005 , vol. 44, # 20 p. 3096 - 3099
  • Route3
    • null|null
      64-17-5
    • (2R,3S)-3-Phenylisoserine hydrochloride Docetaxel  Impurity|CS-0228954
      132201-32-2
    • ~%
    • Ethyl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate|CS-0504135
      143615-00-3

    References

    • SHILPA MEDICARE LIMITED; SHRAWAT, Vimal Kumar; PUROHIT, Prashant; RAFIUDDIN, . Patent: WO2012/117417 A1, 2012 ; Location in patent: Page/Page column 9; 11 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.6104
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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