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tert-Butyl 3-(methylamino)propanoate

  • CAS No. 143707-72-6

  • Cat. No. CS-0124731
  • Molecule weight159.23
  • Purity≥96%
  • MDL No.MFCD08275841

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(methylamino)propanoate|CS-0124731

Structure of 143707-72-6

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General Information

  • CAS No. 143707-72-6
  • Cat. No. CS-0124731
  • Purity ≥96%
  • MDL No. MFCD08275841
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇NO₂
  • Molecular Weight 159.23
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)CCNC

Description

tert-Butyl 3-(methylamino)propanoate features a protected amine handle flanked by a hydrophobic tert-butyl ester, enabling stable incorporation into peptide and small-molecule scaffolds. This robust building block supports efficient coupling reactions under standard conditions, offering reliable access to bioactive analogs in medicinal chemistry workflows.

Application

tert-Butyl 3-(methylamino)propanoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to bioactive amine-containing scaffolds. Its tert-butyl ester group offers excellent bench stability and compatibility with standard deprotection protocols, while the primary methylamino functionality facilitates straightforward derivatization via alkylation, acylation, or reductive amination. The molecule exhibits robust functional group tolerance and is particularly useful in the synthesis of peptidomimetics and heterocyclic intermediates.

Synthesis

  • Route1
    • null|null
      1663-39-4
    • null|null
      593-51-1
    • ~93%
    • In-stock
      tert-Butyl 3-(methylamino)propanoate|CS-0124731
      143707-72-6

    References

    • Universite De Nantes; Chu Nantes; Institut National De La Sante Et De La Recherche Medicale (Inserm); Centre National De La Recherche Scientifique (CNRS) Patent: US2010/311695 A1, 2010 ; Location in patent: Page/Page column 6; 8 ;
  • Route2
    • Tert-butyl 3-[benzyl(methyl)amino]propanoate|CS-0751442
      634916-43-1
    • ~81%
    • In-stock
      tert-Butyl 3-(methylamino)propanoate|CS-0124731
      143707-72-6

    References

    • Howard, Nigel I.; Bugg, Timothy D. H. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 14 p. 3083 - 3099
  • Route3
    • null|null
      1663-39-4
    • ~%
    • In-stock
      tert-Butyl 3-(methylamino)propanoate|CS-0124731
      143707-72-6

    References

    • Pfizer Inc. Patent: US2012/165343 A1, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H315-H318-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   0.9376
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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