Lot numbers can be found on the outside label of a product:
N-benzyloxycarbonyl-3-fluoro-4-morpholinoaniline
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CAS No. 168828-81-7
- Cat. No. CS-0150068
- Purity≥98%
- MDL No.MFCD06658240
*For research and further manufacturing use only, not for direct human use.
Structure of 168828-81-7
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General Information
- CAS No. 168828-81-7
- Cat. No. CS-0150068
- Purity ≥98%
- MDL No. MFCD06658240
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₈H₁₉FN₂O₃
- Molecular Weight 330.35
- Synonym(s) N-CARBOBENZOXY-3-FLUORO-4-MORPHOLINYL-ANILINE
- SMILES FC1=C(N2CCOCC2)C=CC(NC(OCC3=CC=CC=C3)=O)=C1
Description
N-benzyloxycarbonyl-3-fluoro-4-morpholinoaniline features a fluoro-substituted aniline core with a morpholino group enhancing solubility and reactivity. The benzyloxycarbonyl (Cbz) protecting group enables controlled deprotection during peptide synthesis. This compound integrates readily into complex scaffolds requiring electron-rich aromatic systems and handles well under standard bench conditions.
Application
N-Benzyloxycarbonyl-3-fluoro-4-morpholinoaniline serves as a versatile building block for the synthesis of fluorinated aniline derivatives, enabling efficient access to bioactive scaffolds. The morpholino group enhances solubility and modulates electronic properties, while the benzyloxycarbonyl (Z) protection ensures stability during multi-step sequences. This compound facilitates coupling reactions and subsequent deprotection under standard conditions, supporting applications in medicinal chemistry and peptide conjugation workflows.
Synthesis
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Route1
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501-53-1 -
93246-53-8 - ~98%
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In-stock
168828-81-7
References
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Yang, Bo; Shi, Luyan; Wu, Jingjing; Fang, Xiang; Yang, Xueyan; Wu, Fanhong Tetrahedron, 2013 , vol. 69, # 15 p. 3331 - 3337
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Route2
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501-53-1
- ~91%
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In-stock
168828-81-7
References
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LIANHE CHEMICAL TECHNOLOGY CO., LTD. Patent: US2011/275805 A1, 2011 ; Location in patent: Page/Page column 7 ;
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Route3
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In-stock
369-34-6 - ~%
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In-stock
168828-81-7
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 6 p. 857 - 859
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 50.8
- LogP 3.411
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 4
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Key Words
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