(R)-1-Boc-2-Hydroxymethyl-piperazine

CAS No. 169448-87-7
Cat. No. CS-D0658
Purity≥95%
MDL No.MFCD07772092

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(R)-1-Boc-2-Hydroxymethyl-piperazine|CS-D0658

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Description

(R)-1-Boc-2-Hydroxymethyl-piperazine features a chiral piperazine core with a stable Boc-protected amine and a pendant hydroxymethyl group, enabling selective derivatization. This bench-stable scaffold integrates readily into complex molecular architectures, offering enhanced solubility and functional handle versatility in medicinal chemistry workflows.

Application

(R)-1-Boc-2-hydroxymethylpiperazine serves as a versatile chiral building block for the synthesis of bioactive molecules, enabling efficient access to piperazine-based scaffolds. The Boc group provides stable protection of the primary amine, while the pendant hydroxymethyl functionality allows for further derivatization via oxidation or coupling reactions. Its bench-stable nature and compatibility with standard peptide and heterocyclic coupling protocols make it well-suited for medicinal chemistry and process development workflows.

General Information

CAS No. 169448-87-7
Cat. No. CS-D0658
Purity ≥95%
MDL No. MFCD07772092
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₃
Molecular Weight 216.28
Synonym(s) tert-butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate
SMILES O=C(OC(C)(C)C)N1[C@@H](CO)CNCC1

Computational Chemistry Data

TPSA 61.8
LogP 0.1876
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-Boc-2-Hydroxymethyl-piperazine

CAS No. 169448-87-7

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