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CS-W001157 4
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4-Fluoro-2-methoxypyridin-3-amine

  • CAS No. 175965-74-9

  • Cat. No. CS-0163582
  • Purity≥98%
  • MDL No.MFCD18258204
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-methoxypyridin-3-amine|CS-0163582

Structure of 175965-74-9

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Description

4-Fluoro-2-methoxypyridin-3-amine features a fluorinated pyridine core with strategically positioned methoxy and amine groups, enabling selective coupling in medicinal chemistry. The electron-deficient ring facilitates nucleophilic substitution, while the methoxy moiety enhances solubility and metabolic stability. This scaffold serves as a key building block for kinase inhibitors and CNS-targeted therapeutics.

Application

4-Fluoro-2-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. Its fluorine and amine functionalities support diverse coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig couplings, while the methoxy group provides orthogonal reactivity for selective transformations. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating its use in multi-step synthetic sequences targeting bioactive heterocycles.

General Information

  • CAS No. 175965-74-9
  • Cat. No. CS-0163582
  • Purity ≥98%
  • MDL No. MFCD18258204
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂O
  • Molecular Weight 142.13
  • Synonym(s) 4-Fluoro-2-methoxy-3-pyridinamine
  • SMILES NC1=C(F)C=CN=C1OC

Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.8115
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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