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CS-W001157 4
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5-Bromo-2-(difluoromethyl)pyrimidine

  • CAS No. 1780834-92-5

  • Cat. No. CS-0343565
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(difluoromethyl)pyrimidine|CS-0343565

Structure of 1780834-92-5

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General Information

  • CAS No. 1780834-92-5
  • Cat. No. CS-0343565
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrF₂N₂
  • Molecular Weight 208.99
  • Synonym(s) None
  • SMILES FC(C1=NC=C(Br)C=N1)F

Description

5-Bromo-2-(difluoromethyl)pyrimidine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This electron-deficient pyrimidine serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules via cross-coupling reactions.

Application

5-Bromo-2-(difluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromine moiety facilitates C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties. Its bench-stable, crystalline nature supports straightforward handling and purification, making it ideal for constructing bioactive heterocycles and drug-like scaffolds in high-throughput synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.1767
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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