3-Amino-2,5-dichloropyridine

Name: 3-Amino-2,5-dichloropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 78607-32-6
Cat. No. CS-0021999
Purity≥97%
MDL No.MFCD00204157

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 78607-32-6

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Description

3-Amino-2,5-dichloropyridine delivers a highly reactive pyridine scaffold bearing two chlorinated positions and a strategically placed amino group. This combination enables direct coupling reactions in medicinal chemistry and agrochemical synthesis, where regioselective functionalization is critical. The compound exhibits robust stability under standard conditions, facilitating straightforward handling and integration into multi-step transformations.

Application

3-Amino-2,5-dichloropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the amino and chloro positions. Its ortho-dichloro substitution pattern facilitates palladium-catalyzed cross-coupling reactions, while the primary amine group supports acylation, alkylation, and reductive amination. Bench-stable and readily purified by recrystallization, it functions efficiently in the synthesis of heterocyclic scaffolds and API intermediates under standard reaction conditions.

General Information

CAS No. 78607-32-6
Cat. No. CS-0021999
Purity ≥97%
MDL No. MFCD00204157
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄Cl₂N₂
Molecular Weight 163.00
Synonym(s) 2,5-Dichloropyridin-3-amine
SMILES NC1=CC(Cl)=CN=C1Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.9706
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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3-Amino-2,5-dichloropyridine

CAS No. 78607-32-6

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