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Structure of 1783401-69-3
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Quinazoline-8-carboxylic acid features a rigid heteroaromatic core with a carboxylic acid group at the 8-position, enabling direct conjugation or derivatization in medicinal chemistry. This scaffold integrates readily into bioactive molecules, offering enhanced solubility and hydrogen-bonding capacity for target engagement. The electron-deficient quinazoline ring facilitates π-stacking interactions, supporting potency in kinase inhibitor design.
Quinazoline-8-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functional group manipulations. Its carboxylic acid moiety facilitates amide coupling, esterification, and derivatization under mild conditions, while the quinazoline core provides structural rigidity and π-electron delocalization beneficial for target binding. Bench-stable and readily purified by recrystallization, it functions effectively in both small-molecule synthesis and high-throughput screening campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: