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CS-W001157 4
Total: USD 88.00

(3,3-Difluoropiperidin-4-yl)methanol hydrochloride

  • CAS No. 1783945-29-8

  • Cat. No. CS-0053392
  • Molecule weight187.62
  • Purity≥98%
  • MDL No.MFCD27978586

*For research and further manufacturing use only, not for direct human use.

(3,3-Difluoropiperidin-4-yl)methanol hydrochloride|CS-0053392

Structure of 1783945-29-8

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General Information

  • CAS No. 1783945-29-8
  • Cat. No. CS-0053392
  • Purity ≥98%
  • MDL No. MFCD27978586
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClF₂NO
  • Molecular Weight 187.62
  • Synonym(s) None
  • SMILES OCC1CCNCC1(F)F.Cl

Description

This bench-stable, moisture-tolerant building block features a difluorinated piperidine core that enhances metabolic stability and membrane permeability. The hydrochloride salt form ensures excellent solubility in aqueous and polar organic media, facilitating seamless integration into synthetic workflows for medicinal chemistry and drug discovery applications.

Application

(3,3-Difluoropiperidin-4-yl)methanol hydrochloride serves as a valuable building block in medicinal chemistry, enabling the introduction of a difluorinated piperidine motif with enhanced metabolic stability and modulated basicity. The hydrochloride salt ensures excellent bench stability and solubility, facilitating straightforward handling and purification. It functions as a key intermediate in the synthesis of bioactive heterocycles, particularly in projects requiring constrained, fluorinated scaffolds for improved pharmacokinetic profiles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.6453
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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