tert-Butyl 2-(3-aminophenyl)acetate

CAS No. 183180-53-2
Cat. No. CS-0139230
Purity≥96%
MDL No.None

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tert-Butyl 2-(3-aminophenyl)acetate|CS-0139230

Structure of 183180-53-2

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Description

tert-Butyl 2-(3-aminophenyl)acetate features a para-aminophenyl scaffold with a sterically hindered tert-butyl ester, enabling stable incorporation into synthetic sequences. This bench-stable derivative delivers the free amine functionality under standard deprotection conditions, facilitating efficient conjugation in pharmaceutical intermediates and bioconjugation workflows.

Application

tert-Butyl 2-(3-aminophenyl)acetate serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the 3-aminophenyl moiety into target molecules. The tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It exhibits robust functional group tolerance, supporting diverse transformations including Suzuki couplings, Buchwald-Hartwig aminations, and electrophilic substitutions, making it ideal for constructing complex heterocyclic scaffolds and API intermediates.

General Information

CAS No. 183180-53-2
Cat. No. CS-0139230
Purity ≥96%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₇NO₂
Molecular Weight 207.27
Synonym(s) None
SMILES O=C(OC(C)(C)C)CC1=CC=CC(N)=C1

Computational Chemistry Data

TPSA 52.32
LogP 2.153
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-Butyl 2-(3-aminophenyl)acetate

CAS No. 183180-53-2

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