(S)-4-(tert-Butyl)-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole

CAS No. 199277-80-0
Cat. No. CS-0167753
Purity≥97%
MDL No.None

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(S)-4-(tert-Butyl)-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole|CS-0167753

Structure of 199277-80-0

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Description

This chiral oxazole features a tert-butyl group and a 6-methylpyridin-2-yl moiety, delivering enhanced steric bulk and electronic modulation. The dihydrooxazole core provides a stable, bench-ready scaffold for asymmetric synthesis, enabling efficient integration into complex molecular architectures through selective functionalization.

Application

(S)-4-(tert-Butyl)-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of pyridine-containing heterocycles via standard coupling and cyclization protocols. Its stability under ambient conditions and tolerance to diverse functional groups facilitate efficient route development. The dihydrooxazole core functions as a masked α,β-unsaturated carbonyl equivalent, supporting sequential transformations in multi-step syntheses.

General Information

CAS No. 199277-80-0
Cat. No. CS-0167753
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₈N₂O
Molecular Weight 218.29
Synonym(s) 2-[(4S)-4-(tert-Butyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine
SMILES CC1=CC=CC(C2=N[C@@H](C(C)(C)C)CO2)=N1

Computational Chemistry Data

TPSA 34.48
LogP 2.58152
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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(S)-4-(tert-Butyl)-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole

CAS No. 199277-80-0

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