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2-[(4S)-4,5-Dihydro-4-isopropyl-2-oxazolyl]pyridine

  • CAS No. 108915-04-4

  • Cat. No. CS-0086736
  • Molecule weight190.24
  • Purity≥95%
  • MDL No.MFCD28016024

*For research and further manufacturing use only, not for direct human use.

2-[(4S)-4,5-Dihydro-4-isopropyl-2-oxazolyl]pyridine|CS-0086736

Structure of 108915-04-4

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General Information

  • CAS No. 108915-04-4
  • Cat. No. CS-0086736
  • Purity ≥95%
  • MDL No. MFCD28016024
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄N₂O
  • Molecular Weight 190.24
  • Synonym(s) 2-[(4S)-4,5-Dihydro-4-isopropyl-2-oxazolyl]pyridine
  • SMILES CC(C)[C@@H](CO1)N=C1C2=NC=CC=C2

Description

(S)-iPr-Pyox is a bench-stable, chiral pyridine-based ligand featuring a sterically hindered isopropyl group that enhances enantioselectivity in asymmetric catalysis. This electron-rich scaffold enables efficient coordination to transition metals, delivering high diastereo- and enantiocontrol in cross-coupling and reduction reactions under standard conditions.

Application

(S)-iPr-Pyox serves as a highly effective chiral ligand in asymmetric catalysis, enabling enantioselective transformations through well-established coordination with transition metals. Its robust bench stability and excellent functional group tolerance facilitate reliable performance in synthetic workflows, particularly in hydrogenation and conjugate addition reactions. The ligand's modular design supports efficient purification and consistent stereocontrol, making it a practical choice for medicinal chemistry and process development applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   1.883
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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