3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine

CAS No. 20619-12-9
Cat. No. CS-0643566
Purity≥98%
MDL No.MFCD21363476

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3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine|CS-0643566

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Description

A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 M). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.

General Information

CAS No. 20619-12-9
Cat. No. CS-0643566
Purity ≥98%
MDL No. MFCD21363476
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₇ClN₂
Molecular Weight 260.76
Synonym(s) None
SMILES ClC1=CC=C(C(CCNC)C2=NC=CC=C2)C=C1

Computational Chemistry Data

TPSA 24.92
LogP 3.4764
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 5

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine

CAS No. 20619-12-9

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