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3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine

  • CAS No. 20619-12-9

  • Cat. No. CS-0643566
  • Molecule weight260.76
  • Purity≥98%
  • MDL No.MFCD21363476

*For research and further manufacturing use only, not for direct human use.

3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine|CS-0643566

Structure of 20619-12-9

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General Information

  • CAS No. 20619-12-9
  • Cat. No. CS-0643566
  • Purity ≥98%
  • MDL No. MFCD21363476
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₇ClN₂
  • Molecular Weight 260.76
  • Synonym(s) None
  • SMILES ClC1=CC=C(C(CCNC)C2=NC=CC=C2)C=C1

Description

A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 M). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   3.4764
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   5

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