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Structure of 22236-04-0
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2-(Difluoromethoxy)aniline features a difluoromethoxy group attached to the aromatic ring, delivering enhanced metabolic stability and improved lipophilicity compared to simpler anilines. This electron-withdrawing substituent imparts favorable electronic properties for use in medicinal chemistry and agrochemical development. The compound exhibits bench-stable handling characteristics and integrates readily into diverse synthetic transformations.
2-(Difluoromethoxy)aniline serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethoxy group at the ortho position of an aromatic amine. Its robust bench stability and compatibility with standard coupling reactions facilitate efficient incorporation into diverse heterocyclic scaffolds and API intermediates. Functions as a key precursor for bioactive molecules requiring enhanced lipophilicity and metabolic resistance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H302+H312+H332
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Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P501
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Lot numbers can be found on the outside label of a product: