Lenalidomide-F

CAS No. 2359705-88-5
Cat. No. CS-0096964
Purity≥98%
MDL No.MFCD31556181

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

Lenalidomide-F features a fluorinated derivative of lenalidomide, integrating a strategically positioned fluorine atom to enhance metabolic stability and modulate target engagement. This modification improves bioavailability and resistance to enzymatic degradation, enabling prolonged activity in cellular assays. The fluorine substitution enhances electron-withdrawing effects, influencing binding affinity to cereblon and improving potency in immunomodulatory applications.

Application

Lenalidomide-F serves as a key functionalized building block for medicinal chemistry campaigns targeting immunomodulatory drug development. Its fluorinated derivative enables site-specific incorporation into heterocyclic scaffolds, facilitating studies on structure-activity relationships. The molecule exhibits robust bench stability and compatibility with standard coupling protocols, supporting efficient synthesis of analogues via amide and Suzuki-type transformations.

General Information

CAS No. 2359705-88-5
Cat. No. CS-0096964
Purity ≥98%
MDL No. MFCD31556181
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₁FN₂O₃
Molecular Weight 262.24
Synonym(s) None
SMILES O=C(C(N(CC1=C2C=CC=C1F)C2=O)CC3)NC3=O

Computational Chemistry Data

TPSA 66.48
LogP 0.0398
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Lenalidomide-F

CAS No. 2359705-88-5

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