tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate

CAS No. 236406-49-8
Cat. No. CS-B1265
Purity≥96%
MDL No.MFCD03790957

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tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate|CS-B1265

Structure of 236406-49-8

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Description

tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate features a rigid spirocyclic core with strategically positioned nitrogen atoms, enabling efficient incorporation into complex heterocyclic scaffolds. The tert-butyl ester group provides stability and facilitates straightforward deprotection under mild acidic conditions. This compound serves as a key building block in the synthesis of bioactive molecules requiring constrained diamine motifs.

Application

tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and catalytic synthesis. Its tertiary amine functionality and protected carboxylate enable selective functionalization, while the rigid spiro architecture imparts conformational control. The tert-butyl group provides bench stability and facilitates straightforward deprotection under mild acidic conditions, enabling efficient access to free diamine intermediates for downstream applications in heterocycle construction and API development.

General Information

CAS No. 236406-49-8
Cat. No. CS-B1265
Purity ≥96%
MDL No. MFCD03790957
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₂
Molecular Weight 226.32
Synonym(s) tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate; tert-Butyl 3,7-diazaspiro[4.4]nonane-3-carboxylate; tert-Butyl 2,7-diazaspiro[4,4]nonane-2-carboxylate
SMILES O=C(OC(C)(C)C)N(CC1)CC21CNCC2

Computational Chemistry Data

TPSA 41.57
LogP 1.6069
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Spirol Rings compounds

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tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate

CAS No. 236406-49-8

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