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CS-W001157 4
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1-(tert-Butoxycarbonyl)-5,5-dimethylpyrrolidine-3-carboxylic acid

  • CAS No. 2408959-55-5

  • Cat. No. CS-0343278
  • Molecule weight243.30
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-5,5-dimethylpyrrolidine-3-carboxylic acid|CS-0343278

Structure of 2408959-55-5

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General Information

  • CAS No. 2408959-55-5
  • Cat. No. CS-0343278
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) 1,3-Pyrrolidinedicarboxylic acid, 5,5-dimethyl-, 1-(1,1-dimethylethyl) ester
  • SMILES O=C(N1CC(C(O)=O)CC1(C)C)OC(C)(C)C

Description

This protected pyrrolidine carboxylic acid features a tert-butoxycarbonyl group at the nitrogen and two methyl substituents at the 5-position, enhancing stability and steric shielding. The carboxylic acid moiety enables direct incorporation into peptide synthesis or conjugation workflows under standard conditions.

Application

A stable, bench-ready building block for peptide and heterocyclic synthesis, this Boc-protected pyrrolidine derivative facilitates efficient incorporation of sterically hindered proline analogs. Its dimethyl substitution enhances conformational rigidity and metabolic stability, while the carboxylic acid group enables straightforward coupling reactions. Functions as a key intermediate in the construction of bioactive scaffolds and cyclic peptide libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1066
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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