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CS-W001157 4
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tert-Butyl (s)-4-amino-3,3-difluoropiperidine-1-carboxylate

  • CAS No. 2415515-29-4

  • Cat. No. CS-0197696
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (s)-4-amino-3,3-difluoropiperidine-1-carboxylate|CS-0197696

Structure of 2415515-29-4

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Description

tert-Butyl (S)-4-amino-3,3-difluoropiperidine-1-carboxylate features a stereochemically defined piperidine core with dual fluorine atoms at the 3-position, enhancing metabolic stability and membrane permeability. The tert-butyl ester group enables straightforward deprotection under mild acidic conditions, facilitating integration into bioactive molecules. This scaffold serves as a key building block in medicinal chemistry for targeted CNS and oncology drug discovery.

Application

tert-Butyl (S)-4-amino-3,3-difluoropiperidine-1-carboxylate serves as a versatile chiral building block for the synthesis of fluorinated piperidine derivatives. The protected amine and difluoromethylene group enable selective functionalization and stability under standard reaction conditions. Its structural features facilitate incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors. The tert-butyl carbamate group offers ease of removal under mild acidic conditions, supporting efficient downstream processing.

General Information

  • CAS No. 2415515-29-4
  • Cat. No. CS-0197696
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈F₂N₂O₂
  • Molecular Weight 236.26
  • Synonym(s) (S)-tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate
  • SMILES C(OC(C)(C)C)(=O)N1CC(F)(F)[C@@H](N)CC1

Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.5898
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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