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Structure of 248274-16-0
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1-(5-(Trifluoromethyl)pyridin-2-yl)ethan-1-one features a trifluoromethyl-substituted pyridine ring coupled to an acetyl group, delivering enhanced electron-withdrawing character and improved metabolic stability. This structure enables efficient integration into pharmaceutical intermediates and functional materials. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating straightforward handling in synthetic workflows.
1-(5-(Trifluoromethyl)pyridin-2-yl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based pharmacophores. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the acetyl functionality facilitates nucleophilic addition, Grignard reactions, and transition-metal-catalyzed couplings. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it ideal for iterative synthesis of API candidates and heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: