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Ethyl 4-chloro-1,7-naphthyridine-2-carboxylate

  • CAS No. 250674-51-2

  • Cat. No. CS-0105382
  • Molecule weight236.65
  • Purity≥96%
  • MDL No.MFCD21340214

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-chloro-1,7-naphthyridine-2-carboxylate|CS-0105382

Structure of 250674-51-2

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General Information

  • CAS No. 250674-51-2
  • Cat. No. CS-0105382
  • Purity ≥96%
  • MDL No. MFCD21340214
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉ClN₂O₂
  • Molecular Weight 236.65
  • Synonym(s) Ethyl 4-chloro-1,7-naphthidine-2-carboxylate
  • SMILES O=C(C1=NC2=CN=CC=C2C(Cl)=C1)OCC

Description

Ethyl 4-chloro-1,7-naphthyridine-2-carboxylate features a chlorinated naphthyridine core with a bench-stable ester handle, enabling direct integration into cross-coupling and heterocyclic elaboration workflows. The electron-deficient ring system supports efficient functionalization under palladium catalysis, while the para-chloro substitution provides a reactive site for nucleophilic displacement.

Application

Ethyl 4-chloro-1,7-naphthyridine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The ester group provides synthetic handle for further derivatization, while the naphthyridine core offers structural rigidity and π-system extension useful in medicinal chemistry. Bench-stable and readily purified by chromatography or recrystallization, it functions effectively in standard coupling protocols and facilitates the construction of complex polycyclic scaffolds relevant to pharmaceutical research.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   2.4599
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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