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CS-W001157 4
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2,2-Dimethyltetrahydro-2H-pyran-4-ylamine

  • CAS No. 25850-22-0

  • Cat. No. CS-D0455
  • Molecule weight129.20
  • Purity≥95%
  • MDL No.MFCD00778609

*For research and further manufacturing use only, not for direct human use.

2,2-Dimethyltetrahydro-2H-pyran-4-ylamine|CS-D0455

Structure of 25850-22-0

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General Information

  • CAS No. 25850-22-0
  • Cat. No. CS-D0455
  • Purity ≥95%
  • MDL No. MFCD00778609
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) 2,2-dimethyltetrahydro-2H-pyran-4-amine
  • SMILES NC1CC(C)(C)OCC1

Description

This bench-stable amine features a rigid tetrahydropyran core with a sterically shielded dimethyl substitution, enhancing metabolic stability. The primary amine functionality enables straightforward conjugation and incorporation into bioactive scaffolds.

Application

2,2-Dimethyltetrahydro-2H-pyran-4-ylamine serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its tertiary amine functionality enables efficient salt formation and solubility modulation, while the rigid pyran scaffold provides conformational stability. The geminal dimethyl substitution enhances metabolic resistance and bench stability, facilitating straightforward purification. It functions effectively in amide coupling, alkylation, and transition-metal-catalyzed cross-coupling reactions, supporting rapid diversification in API lead optimization.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H226-H302-H318
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.9027
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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