Lot numbers can be found on the outside label of a product:
Methyl 4-aminothiazole-5-carboxylate
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CAS No. 278183-10-1
- Cat. No. CS-D1071
- Purity≥98%
- MDL No.MFCD09033876
*For research and further manufacturing use only, not for direct human use.
Structure of 278183-10-1
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General Information
- CAS No. 278183-10-1
- Cat. No. CS-D1071
- Purity ≥98%
- MDL No. MFCD09033876
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₆N₂O₂S
- Molecular Weight 158.18
- Synonym(s) Methyl 4-amino-5-thiazolecarboxylate
- SMILES O=C(C1=C(N)N=CS1)OC
Description
Methyl 4-aminothiazole-5-carboxylate features a bifunctional thiazole scaffold integrating an amino group and a methyl ester, enabling direct incorporation into diverse heterocyclic architectures. This bench-stable, moisture-tolerant building block facilitates efficient access to bioactive compounds through coupling reactions and transition-metal-catalyzed transformations.
Application
Methyl 4-aminothiazole-5-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds through standard coupling and functionalization reactions. The amino and ester groups offer orthogonal reactivity, facilitating sequential modifications. Bench-stable and readily purified by recrystallization, it functions effectively in multistep syntheses of heterocyclic intermediates and API candidates.
Synthesis
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Route1
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In-stock
60093-05-2 - ~24%
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In-stock
278183-10-1
References
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MERCK SHARP and DOHME LIMITED; HOLLINGWORTH, Gregory, John; JONES, A., Brian; SPAREY, Timothy, Jason Patent: WO2005/49613 A1, 2005 ; Location in patent: Page/Page column 42 ; WO 2005/049613 A1
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Route2
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951804-64-1 - ~%
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In-stock
278183-10-1
References
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Eisai RandD Management Co., Ltd. Patent: US2009/270433 A1, 2009 ; Location in patent: Page/Page column 27 ;
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Route3
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In-stock
60093-05-2
- ~34%
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74-93-1 -
In-stock
278183-10-1
References
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BAYER PHARMACEUTICALS CORPORATION Patent: WO2006/96338 A1, 2006 ; Location in patent: Page/Page column 30-31 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 65.21
- LogP 0.5119
- H_Acceptors 5
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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