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Structure of 28177-48-2
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2,6-difluorophenol undergoes oxidative polymerization in the presence of the Fe-N,N-bis(salicylidene)ethylenediamine (salen) complex (catalyst) and hydrogen peroxide (oxidizing agent) to give poly(2,6-difluoro-1,4-phenylene oxide).
2,6-Difluorophenol serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability through fluorine substitution at the ortho positions. Its phenolic functionality enables direct coupling reactions, including Suzuki-Miyaura and Ullmann-type transformations, while the difluoro substitution pattern imparts favorable electronic and steric properties. The compound exhibits good bench stability and is readily purified by standard techniques, facilitating its use in multi-step syntheses of functionalized aromatic scaffolds.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1325
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Class : 4.1
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Packing Group : Ⅱ
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Hazard Statements : H228-H315-H319-H335
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Precautionary Statements : P210-P240-P241-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: