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CS-W001157 4
Total: USD 88.00

2-Fluorophenol

  • CAS No. 367-12-4

  • Cat. No. CS-0018719
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00002155

*For research and further manufacturing use only, not for direct human use.

2-Fluorophenol|CS-0018719

Structure of 367-12-4

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General Information

  • CAS No. 367-12-4
  • Cat. No. CS-0018719
  • Purity ≥98%
  • MDL No. MFCD00002155
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FO
  • Molecular Weight None
  • Synonym(s) o-Fluorophenol
  • SMILES FC1=C(O)C=CC=C1

Description

2-Fluorophenol delivers a reactive ortho-fluorinated aromatic scaffold ideal for pharmaceutical and agrochemical synthesis. The fluorine substituent enhances metabolic stability and modulates electronic properties, while the phenolic hydroxyl enables direct functionalization or hydrogen bonding in target molecules. This bench-stable compound integrates readily into complex molecular architectures under standard conditions.

Application

2-Fluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the ortho position relative to the hydroxyl group. Its enhanced electrophilicity compared to phenol facilitates nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it suitable for multi-step syntheses.

Synthesis

  • Route1

    References

    • Mulakayala, Naveen; Ismail; Kumar, Kottur Mohan; Rapolu, Rajesh Kumar; Kandagatla, Bhaskar; Rao, Pallavi; Oruganti, Srinivas; Pal, Manojit Tetrahedron Letters, 2012 , vol. 53, # 45 p. 6004 - 6007,4
  • Route2
    • null|null
      1338215-32-9
    • ~86%
    • In-stock
      2-Fluorophenol|CS-0018719
      367-12-4

    References

    • Dibakar, Mullick; Prakash, Anjanappa; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5338 - 5341
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    References

    • Sindelar; Holubek; Ryska; et al. Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 1 p. 72 - 87

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Warning
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.5313
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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