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Structure of 287193-00-4
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tert-Butyl 3-ethynylpyrrolidine-1-carboxylate delivers a synthetically accessible pyrrolidine scaffold featuring a terminal alkyne handle. This bench-stable, moisture-tolerant reagent enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for site-specific conjugation in drug discovery and chemical biology applications.
tert-Butyl 3-ethynylpyrrolidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrroline and pyrrolidine scaffolds via Pd-catalyzed coupling reactions. The terminal alkyne group facilitates Sonogashira, Huisgen cycloaddition, and other transition-metal-mediated transformations. Its tert-butyl carbamate protecting group offers excellent bench stability and compatibility with diverse reaction conditions, simplifying purification and enabling straightforward deprotection to the free amine.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: