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Structure of 33089-15-5
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4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile is a heterocyclic building block featuring a chlorinated pyrimidine core with orthogonal functional handles: a methylthio group and a nitrile moiety. This combination enables selective derivatization in medicinal chemistry, particularly for kinase inhibitors and nucleoside analogs. The molecule exhibits enhanced stability under standard bench conditions and facilitates efficient coupling reactions via the carbonitrile or halogen sites.
4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its orthogonal functional groups—chloride, methylthio, and nitrile—facilitate sequential transformations via nucleophilic substitution, cross-coupling, and cyanide derivatization. The compound exhibits excellent bench stability and is compatible with standard reaction conditions, simplifying purification and scale-up in API synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: