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CS-W001157 4
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4-(Tert-butyl)pyridin-2-amine

  • CAS No. 33252-26-5

  • Cat. No. CS-0323513
  • Molecule weight150.22
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Tert-butyl)pyridin-2-amine|CS-0323513

Structure of 33252-26-5

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General Information

  • CAS No. 33252-26-5
  • Cat. No. CS-0323513
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄N₂
  • Molecular Weight 150.22
  • Synonym(s) 4-tert-butylpyridin-2-amine
  • SMILES NC1=NC=CC(C(C)(C)C)=C1

Description

4-(Tert-butyl)pyridin-2-amine features a sterically hindered tert-butyl group that enhances solubility and stability while the pyridine nitrogen provides a strong ligating site. This combination enables efficient coordination in transition metal catalysis and facilitates modular synthesis in pharmaceutical intermediates.

Application

4-(Tert-butyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its pyridine nitrogen and primary amine facilitate metal-catalyzed cross-couplings and derivatization, while the bulky tert-butyl group enhances steric protection and metabolic stability. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process-scale applications.

Synthesis

  • Route1

    References

    • Merck and Co., Inc. Patent: US6248755 B1, 2001 ; US 6248755 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.9613
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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