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CS-W001157 4
Total: USD 88.00

tert-Butyl (1-(bromomethyl)cyclopropyl)carbamate

  • CAS No. 387845-49-0

  • Cat. No. CS-0088314
  • Purity≥97%
  • MDL No.MFCD23701521
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (1-(bromomethyl)cyclopropyl)carbamate|CS-0088314

Structure of 387845-49-0

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Description

tert-Butyl (1-(bromomethyl)cyclopropyl)carbamate delivers a cyclopropyl ring tethered to a bromomethyl group, enabling direct functionalization at the strained ring junction. The tert-butyl carbamate moiety provides stability and ease of removal under mild acidic conditions. This reagent facilitates efficient incorporation of cyclopropyl motifs into complex molecular architectures.

Application

tert-Butyl (1-(bromomethyl)cyclopropyl)carbamate serves as a versatile building block for cyclopropyl-containing scaffolds in medicinal chemistry. The bromomethyl group enables efficient nucleophilic substitution, facilitating C–C and C–heteroatom bond formation under mild conditions. Its tert-butyl carbamate protection offers excellent bench stability and compatibility with diverse reaction environments, simplifying purification and enabling sequential functionalization. This reagent is particularly valuable for constructing bioactive cyclopropyl motifs in API development.

General Information

  • CAS No. 387845-49-0
  • Cat. No. CS-0088314
  • Purity ≥97%
  • MDL No. MFCD23701521
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₆BrNO₂
  • Molecular Weight 250.13
  • Synonym(s) Tert-butyl n-[1-(bromomethyl)cyclopropyl]carbamate
  • SMILES BrCC1(NC(OC(C)(C)C)=O)CC1

Computational Chemistry Data

  • TPSA   38.33
  • LogP   2.4386
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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