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Structure of 39226-97-6
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2-Chloro-3-(trifluoromethyl)benzoic acid features a strategically positioned trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This combination enables efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.
2-Chloro-3-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient incorporation of electron-withdrawing trifluoromethyl and chloro substituents into aromatic scaffolds. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the ortho-chloro group offers compatibility with palladium-catalyzed cross-coupling processes. Bench-stable and readily purified by recrystallization, it functions as a reliable intermediate for constructing complex heterocyclic systems and bioactive molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: