tert-Butyl 4-(1-aminoethyl)piperidine-1-carboxylate

CAS No. 455267-29-5
Cat. No. CS-W000541
Purity≥97%
MDL No.MFCD11045798

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tert-Butyl 4-(1-aminoethyl)piperidine-1-carboxylate|CS-W000541

Structure of 455267-29-5

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Description

tert-Butyl 4-(1-aminoethyl)piperidine-1-carboxylate features a piperidine core bearing a tert-butyl ester and primary amine-functionalized side chain, enabling direct incorporation into peptide and small-molecule scaffolds. The protected amine facilitates sequential coupling without racemization, while the tert-butyl group ensures stability under standard bench conditions. This building block supports efficient access to bioactive nitrogen-rich compounds in medicinal chemistry workflows.

Application

tert-Butyl 4-(1-aminoethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the construction of piperidine-based scaffolds through standard deprotection and functionalization protocols. The tert-butyl carbamate group offers excellent bench stability and orthogonal compatibility with common protecting groups, while the primary amine supports facile derivatization via acylation, alkylation, or coupling reactions. Its structure facilitates rapid access to bioactive analogs in target-directed synthesis.

General Information

CAS No. 455267-29-5
Cat. No. CS-W000541
Purity ≥97%
MDL No. MFCD11045798
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₄N₂O₂
Molecular Weight 228.33
Synonym(s) 4-(1-Amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
SMILES CC(N)C1CCN(CC1)C(=O)OC(C)(C)C

Computational Chemistry Data

TPSA 55.56
LogP 1.9807
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-(1-aminoethyl)piperidine-1-carboxylate

CAS No. 455267-29-5

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