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Structure of 49708-81-8
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trans-4-(4-Chlorophenyl)cyclohexanecarboxylic acid features a rigid cyclohexane core with a para-chlorophenyl substituent and a carboxylic acid handle, enabling integration into bioactive scaffolds. The trans configuration ensures optimal spatial orientation for target engagement, while the electron-withdrawing chlorine enhances metabolic stability. This bench-stable derivative serves as a key building block in medicinal chemistry campaigns targeting GPCR modulators and kinase inhibitors.
trans-4-(4-Chlorophenyl)cyclohexanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through established functional group transformations. Its stable cyclohexane core and ortho-directed substituents facilitate regioselective derivatization, while the carboxylic acid group supports direct coupling or salt formation. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: