1-Methyl-4-(piperidin-4-yl)piperazine

CAS No. 53617-36-0
Cat. No. CS-M1225
Purity≥97%
MDL No.MFCD03274729

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1-Methyl-4-(piperidin-4-yl)piperazine|CS-M1225

Structure of 53617-36-0

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Description

1-Methyl-4-(piperidin-4-yl)piperazine is a nitrogen-rich heterocyclic scaffold featuring a piperazine core with a methylated terminal amine and a secondary amine-bearing piperidine ring. This structure delivers enhanced solubility and metabolic stability, enabling efficient integration into medicinal chemistry libraries. The molecule's basicity and hydrogen-bonding capacity support strong target engagement in CNS-directed drug discovery.

Application

1-Methyl-4-(piperidin-4-yl)piperazine serves as a versatile nitrogen-rich scaffold in medicinal chemistry, enabling the construction of diverse heterocyclic systems. Its functional group tolerance and solubility profile facilitate efficient coupling reactions and downstream derivatization. The molecule functions as a key building block in the synthesis of bioactive compounds, particularly those requiring extended conformational flexibility and hydrogen-bonding capacity. Bench-stable and amenable to standard purification techniques, it supports scalable synthesis workflows.

General Information

CAS No. 53617-36-0
Cat. No. CS-M1225
Purity ≥97%
MDL No. MFCD03274729
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₁N₃
Molecular Weight 183.29
Synonym(s) Piperazine, 1-methyl-4-(4-piperidinyl)-
SMILES CN1CCN(CC1)C2CCNCC2

Computational Chemistry Data

TPSA 18.51
LogP -0.0142
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302+H312-H314
Precautionary Statements : P264-P270-P280-P304+P340-P330-P331-P363-P403-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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1-Methyl-4-(piperidin-4-yl)piperazine

CAS No. 53617-36-0

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