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Structure of 454-16-0
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2-Fluoro-5-nitroanisole features a fluorinated aromatic ring paired with a nitro group and methoxy substituent, enabling selective coupling in cross-coupling reactions. The electron-deficient aryl fluoride facilitates palladium-catalyzed transformations, while the methoxy group enhances solubility and stability under standard conditions. This combination delivers efficient access to complex heterocyclic architectures in medicinal chemistry and materials synthesis.
2-Fluoro-5-nitroanisole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the aromatic ring via Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Its fluorine and nitro groups provide orthogonal reactivity, while the methoxy group enhances solubility and facilitates downstream transformations. Bench-stable and readily purified by column chromatography, it functions efficiently in multi-step synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: