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Structure of 54745-74-3
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8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride is a rigid, nitrogen-containing heterocycle featuring a bridged oxygen atom and a protonated amine. This structure imparts enhanced solubility and metabolic stability, making it a valuable scaffold in medicinal chemistry for targeting GPCRs and ion channels.
8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride serves as a rigid, conformationally constrained scaffold for medicinal chemistry applications. Its bridged structure provides enhanced metabolic stability and defined spatial orientation of substituents, facilitating targeted interactions in biological systems. The compound exhibits excellent bench stability, tolerates a range of functional groups, and enables efficient derivatization via nucleophilic substitution or reductive amination. This makes it a practical building block for the synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: