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CS-W001157 4
Total: USD 88.00

VcMMAE

  • CAS No. 646502-53-6

  • Cat. No. CS-1242
  • Molecule weight1316.63
  • Purity≥98%
  • MDL No.MFCD25372036

*For research and further manufacturing use only, not for direct human use.

VcMMAE|CS-1242

Structure of 646502-53-6

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General Information

  • CAS No. 646502-53-6
  • Cat. No. CS-1242
  • Purity ≥98%
  • MDL No. MFCD25372036
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆₈H₁₀₅N₁₁O₁₅
  • Molecular Weight 1316.63
  • Synonym(s) MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
  • SMILES CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(CCCCCN4C(C=CC4=O)=O)=O

Description

VcMMAE features a vinyl carbonate moiety paired with a maleimide group, enabling rapid, site-specific conjugation under physiological conditions. This bifunctional linker integrates seamlessly into antibody-drug conjugate workflows, delivering stable linkages with controlled payload release.

Application

VcMMAE serves as a potent cytotoxic payload in antibody-drug conjugates, enabling targeted delivery to cancer cells. Its valine-citrulline linker provides protease-sensitive cleavage, ensuring controlled release within the intracellular environment. The maleimide moiety facilitates site-specific conjugation to cysteine residues on monoclonal antibodies. This combination offers high stability in circulation and efficient intracellular activation, making VcMMAE a well-established building block for next-generation biopharmaceuticals.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H300+H330-H340-H360-H370-H372-H412
Precautionary Statements : P260-P264-P270-P271-P273-P280-P284-P304+P340-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   346.85
  • LogP   5.077
  • H_Acceptors   15
  • H_Donors   8
  • Rotatable_Bonds   38

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