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Structure of 64744-50-9
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4,4-Pentamethylene-2-pyrrolidinone (2-azaspiro[4.5]decan-3-one, gabapentin-lactam) is a degradation product of gabapentin.
2-Azaspiro[4.5]decan-3-one serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functional group manipulations. Its rigid spirocyclic framework provides conformational constraint, enhancing target binding affinity. The ketone and nitrogen functionalities offer reliable handles for derivatization, including reductive amination and nucleophilic addition. Bench-stable and compatible with common reaction conditions, it facilitates efficient access to complex molecular architectures in lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS08
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H361
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Precautionary Statements : P201-P202-P280-P308+P313-P405-P501
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Lot numbers can be found on the outside label of a product: