1-(Methylsulfonyl)piperidin-4-amine hydrochloride

CAS No. 651057-01-1
Cat. No. CS-W021256
Molecule weight214.71
Purity≥97%
MDL No.MFCD08690153

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1-(Methylsulfonyl)piperidin-4-amine hydrochloride|CS-W021256

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General Information

CAS No. 651057-01-1
Cat. No. CS-W021256
Purity ≥97%
MDL No. MFCD08690153
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₅ClN₂O₂S
Molecular Weight 214.71
Synonym(s) 4-Amino-1-(methylsulfonyl)piperidine Hydrochloride
SMILES NC1CCN(S(=O)(C)=O)CC1.[H]Cl

Description

This piperidine derivative features a methylsulfonyl group that enhances solubility and metabolic stability, while the amine functionality enables straightforward derivatization. The hydrochloride salt form ensures improved crystallinity and handling under standard laboratory conditions.

Application

1-(Methylsulfonyl)piperidin-4-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard amine functionalization. The methylsulfonyl group enhances solubility and metabolic stability, while the piperidinyl amine moiety facilitates conjugation via amidation, alkylation, or reductive amination. Its crystalline solid form ensures excellent bench stability and ease of handling, supporting scalable synthesis and purification workflows.

Synthesis

Route1
- 287953-38-2
- ~99%
- In-stock
  
  651057-01-1
References
- ASTEX THERAPEUTICS LIMITED Patent: WO2006/77414 A1, 2006 ; Location in patent: Page/Page column 164 ; WO 2006/077414 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.4
LogP -0.2091
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfone

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-(Methylsulfonyl)piperidin-4-amine hydrochloride

CAS No. 651057-01-1

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